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For most travelers a safari to East Africa raises number of questions regarding health issues. SLA have provided guidelines below:

Immunisation against typhoid is highly recommended. A yellow fever vaccination certificate is required from travellers over one year of age. Find out from your medical practitioner if your country is classified as an endemic zone. For such visitors the vaccine is mandatory. Travellers arriving from non-endemic zones should note that vaccination is strongly recommended for travel outside the urban areas, even if an outbreak of the disease has not been reported.

A cholera vaccination certificate is not mandatory for entry to Kenya, Tanzania and Uganda. However, cholera is a serious risk in Kenya, Tanzania and Uganda and precautions should be taken. Talk to your doctor before travelling to these countries.
Malaria risk exists all over the country. It is advisable to take anti-malaria tabs before travelling to Kenya and Tanzania and especially the coastal regions. Nairobi and Arusha are relatively safer when it comes to malaria attacks.
The vast majority of traveler's to Africa return from their safaris happy and healthy!
No matter where you travel in East Africa a course of anti malaria tablets is essential. We recommend that you consult with your medical practitioner for further details.